Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO

Activated dsRNA-dependent serine/threonine kinase PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2α), resulting in a shut-off of general translation, induction of apoptosis, and inhibition of virus replication. PKR can be activated by binding to dsRNA or cellular proteins...

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Udgivet i:Sci Rep
Main Authors: de la Cruz-Herrera, Carlos F., Baz-Martínez, Maite, Motiam, Ahmed El, Vidal, Santiago, Collado, Manuel, Vidal, Anxo, Rodríguez, Manuel S., Esteban, Mariano, Rivas, Carmen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656663/
https://ncbi.nlm.nih.gov/pubmed/29070839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12777-7
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