Activation of the Double-stranded RNA-dependent Protein Kinase PKR by Small Ubiquitin-like Modifier (SUMO)

The dsRNA-dependent kinase PKR is an interferon-inducible protein with ability to phosphorylate the α subunit of the eukaryotic initiation factor (eIF)-2 complex, resulting in a shut-off of general translation, induction of apoptosis, and inhibition of virus replication. Here we analyzed the modific...

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Main Authors: de la Cruz-Herrera, Carlos F., Campagna, Michela, García, Maria A., Marcos-Villar, Laura, Lang, Valerie, Baz-Martínez, Maite, Gutiérrez, Sylvia, Vidal, Anxo, Rodríguez, Manuel S., Esteban, Mariano, Rivas, Carmen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176227/
https://ncbi.nlm.nih.gov/pubmed/25074923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.560961
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