Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair

Severely injured patients frequently suffer compromised fracture healing because of systemic post-traumatic inflammation. An important trigger of the posttraumatic immune response is the complement anaphylatoxin C5a, which acts via two receptors, C5aR1 and C5aR2, expressed on immune and bone cells....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kovtun, Anna, Bergdolt, Stephanie, Hägele, Yvonne, Matthes, Rebekka, Lambris, John D., Huber-Lang, Markus, Ignatius, Anita
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656620/
https://ncbi.nlm.nih.gov/pubmed/29070810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14444-3
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