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Impaired BK(Ca) channel function in native vascular smooth muscle from humans with type 2 diabetes

Large-conductance Ca(2+)-activated potassium (BK(Ca)) channels are key determinants of vascular smooth muscle excitability. Impaired BK(Ca) channel function through remodeling of BK(Ca) β1 expression and function contributes to vascular complications in animal models of diabetes. Yet, whether simila...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Nieves-Cintrón, Madeline, Syed, Arsalan U., Buonarati, Olivia R., Rigor, Robert R., Nystoriak, Matthew A., Ghosh, Debapriya, Sasse, Kent C., Ward, Sean M., Santana, Luis F., Hell, Johannes W., Navedo, Manuel F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656614/
https://ncbi.nlm.nih.gov/pubmed/29070899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14565-9
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