Significant variation between SNP-based HLA imputations in diverse populations: The last mile is the hardest

Four SNP-based HLA imputation methods (e-HLA, HIBAG, HLA*IMP:02 and MAGPrediction) were trained using 1000 Genomes SNP and HLA genotypes and assessed for their ability to accurately impute molecular HLA-A, -B, -C, and –DRB1 genotypes in the Human Genome Diversity Project cell panel. Imputation conco...

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Bibliografske podrobnosti
izdano v:Pharmacogenomics J
Main Authors: Pappas, Derek J., Lizee, Antoine, Paunic, Vanja, Beutner, Karl R., Motyer, Allan, Vukcevic, Damjan, Leslie, Stephen, Biesiada, Jacek, Meller, Jarek, Taylor, Kent D., Zheng, Xiuwen, Zhao, Lue Ping, Gourraud, Pierre-Antoine, Hollenbach, Jill A., Mack, Steven J., Maiers, Martin
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656547/
https://ncbi.nlm.nih.gov/pubmed/28440342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2017.7
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