SNP imputation bias reduces effect size determination

Imputation is a commonly used technique that exploits linkage disequilibrium to infer missing genotypes in genetic datasets, using a well-characterized reference population. While there is agreement that the reference population has to match the ethnicity of the query dataset, it is common practice...

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Udgivet i:Front Genet
Main Authors: Khankhanian, Pouya, Din, Lennox, Caillier, Stacy J., Gourraud, Pierre-Antoine, Baranzini, Sergio E.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321633/
https://ncbi.nlm.nih.gov/pubmed/25709616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00030
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