Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis

The sequential use of signaling pathways is essential for the guidance of pluripotent progenitors into diverse cell fates. Here, we show that Shp2 exclusively mediates FGF but not PDGF signaling in the neural crest to control lacrimal gland development. In addition to preventing p53-independent apop...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Garg, Ankur, Bansal, Mukesh, Gotoh, Noriko, Feng, Gen-Sheng, Zhong, Jian, Wang, Fen, Kariminejad, Ariana, Brooks, Steven, Zhang, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656309/
https://ncbi.nlm.nih.gov/pubmed/29028795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007047
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