Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis

The sequential use of signaling pathways is essential for the guidance of pluripotent progenitors into diverse cell fates. Here, we show that Shp2 exclusively mediates FGF but not PDGF signaling in the neural crest to control lacrimal gland development. In addition to preventing p53-independent apop...

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Vydáno v:PLoS Genet
Hlavní autoři: Garg, Ankur, Bansal, Mukesh, Gotoh, Noriko, Feng, Gen-Sheng, Zhong, Jian, Wang, Fen, Kariminejad, Ariana, Brooks, Steven, Zhang, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656309/
https://ncbi.nlm.nih.gov/pubmed/29028795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007047
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