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In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells

The progression of Alzheimer’s disease is causatively linked to the accumulation of amyloid-β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the death of neuronal cells. The in vitro toxic effects of amyloid peptides are most commonly examined using the human n...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Krishtal, Jekaterina, Bragina, Olga, Metsla, Kristel, Palumaa, Peep, Tõugu, Vello
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655426/
https://ncbi.nlm.nih.gov/pubmed/29065138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186636
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