Simultaneous silencing of TGF-β1 and COX-2 reduces human skin hypertrophic scar through activation of fibroblast apoptosis

Excessive skin scars due to elective operations or trauma represent a challenging clinical problem. Pathophysiology of hypertrophic scars entails a prolonged inflammatory and proliferative phase of wound healing. Over expression of TGF-β1 and COX-2 play key regulatory roles of the aberrant fibrogeni...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhou, Jia, Zhao, Yixuan, Simonenko, Vera, Xu, John J., Liu, Kai, Wang, Deling, Shi, Jingli, Zhong, Tianyi, Zhang, Lixia, Zeng, Lun, Huang, Bin, Tang, Shenggao, Lu, Alan Y., Mixson, A. James, Sun, Yangbai, Lu, Patrick Y., Li, Qingfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655228/
https://ncbi.nlm.nih.gov/pubmed/29113333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20869
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