Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene

Combinations of antibiotics, each individually effective against Mycobacterium abscessus, are routinely coadministered based on the concept that this minimizes the spread of antibiotic resistance. However, our in vitro data contradict this assumption and instead document antagonistic interactions be...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Pryjma, Mark, Burian, Ján, Kuchinski, Kevin, Thompson, Charles J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655113/
https://ncbi.nlm.nih.gov/pubmed/28874379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01353-17
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