Dual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis

New chemotherapeutic agents with novel mechanisms of action are urgently required to combat the challenge imposed by the emergence of drug-resistant mycobacteria. In this study, a phenotypic whole-cell screen identified 5-nitro-1,10-phenanthroline (5NP) as a lead compound. 5NP-resistant isolates har...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Kidwai, Saqib, Park, Chan-Yong, Mawatwal, Shradha, Tiwari, Prabhakar, Jung, Myung Geun, Gosain, Tannu Priya, Kumar, Pradeep, Alland, David, Kumar, Sandeep, Bajaj, Avinash, Hwang, Yun-Kyung, Song, Chang Sik, Dhiman, Rohan, Lee, Ill Young, Singh, Ramandeep
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655107/
https://ncbi.nlm.nih.gov/pubmed/28893784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00969-17
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