Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli

Fosfomycin exhibits broad-spectrum antibacterial activity and is being reevaluated for the treatment of extensively drug-resistant pathogens. Its activity in Gram-negative organisms, however, can be compromised by expression of FosA, a metal-dependent transferase that catalyzes the conjugation of gl...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Klontz, Erik H., Tomich, Adam D., Günther, Sebastian, Lemkul, Justin A., Deredge, Daniel, Silverstein, Zach, Shaw, JoAnna F., McElheny, Christi, Doi, Yohei, Wintrode, Patrick L., MacKerell, Alexander D., Sluis-Cremer, Nicolas, Sundberg, Eric J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655077/
https://ncbi.nlm.nih.gov/pubmed/28874374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01572-17
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