Inhibition of Fosfomycin Resistance Protein FosA by Phosphonoformate (Foscarnet) in Multidrug-Resistant Gram-Negative Pathogens

FosA proteins confer fosfomycin resistance to Gram-negative pathogens via glutathione-mediated modification of the antibiotic. In this study, we assessed whether inhibition of FosA by sodium phosphonoformate (PPF) (foscarnet), a clinically approved antiviral agent, would reverse fosfomycin resistanc...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Ito, Ryota, Tomich, Adam D., McElheny, Christi L., Mettus, Roberta T., Sluis-Cremer, Nicolas, Doi, Yohei
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700359/
https://ncbi.nlm.nih.gov/pubmed/28993329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01424-17
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