Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several of which have been implicated in aberrant fibroblast activation in fibrotic diseases including systemic sclerosis (SSc). Here we show that profibrotic signals converge on STAT3 and that STAT3 may...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Chakraborty, Debomita, Šumová, Barbora, Mallano, Tatjana, Chen, Chih-Wei, Distler, Alfiya, Bergmann, Christina, Ludolph, Ingo, Horch, Raymund E., Gelse, Kolja, Ramming, Andreas, Distler, Oliver, Schett, Georg, Šenolt, Ladislav, Distler, Jörg H. W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654983/
https://ncbi.nlm.nih.gov/pubmed/29066712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01236-6
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