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Impaired K(+) binding to glial glutamate transporter EAAT1 in migraine

SLC1A3 encodes the glial glutamate transporter hEAAT1, which removes glutamate from the synaptic cleft via stoichiometrically coupled Na(+)-K(+)-H(+)-glutamate transport. In a young man with migraine with aura including hemiplegia, we identified a novel SLC1A3 mutation that predicts the substitution...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kovermann, Peter, Hessel, Margarita, Kortzak, Daniel, Jen, Joanna C., Koch, Johannes, Fahlke, Christoph, Freilinger, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654970/
https://ncbi.nlm.nih.gov/pubmed/29066757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14176-4
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