Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis

Recently, we reported that clofazimine (CF) has an anti-piroplasm activity, but it could not completely eliminate parasites in the host. The currently available anti-piroplasm drug, diminazene aceturate (DA), has sometimes been reported to have toxic side effects. In the present study, we evaluated...

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Publicado no:Sci Rep
Main Authors: Tuvshintulga, Bumduuren, AbouLaila, Mahmoud, Sivakumar, Thillaiampalam, Tayebwa, Dickson Stuart, Gantuya, Sambuu, Naranbaatar, Khandsuren, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi, Terkawi, Mohamad Alaa, Guswanto, Azirwan, Rizk, Mohamed Abdo, Yokoyama, Naoaki, Igarashi, Ikuo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654833/
https://ncbi.nlm.nih.gov/pubmed/29066849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14304-0
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