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ECM turnover-stimulated gene delivery through collagen-mimetic peptide-plasmid integration in collagen

Gene therapies have great potential in regenerative medicine; however, clinical translation has been inhibited by low stability and limited transfection efficiencies. Herein, we incorporate collagen-mimetic peptide (CMP)-linked polyplexes in collagen scaffolds to increase DNA stability by up to 400%...

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Bibliografische gegevens
Gepubliceerd in:Acta Biomater
Hoofdauteurs: Urello, Morgan A., Kiick, Kristi L., Sullivan, Millicent O.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654588/
https://ncbi.nlm.nih.gov/pubmed/28865990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2017.08.038
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