Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity

BACKGROUND AND AIMS: Pannexins constitute a relatively new family of transmembrane proteins that form channels linking the cytoplasmic compartment with the extracellular environment. Presence of pannexin1 in the liver has been documented previously, where it underlies inflammatory responses, such as...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Toxicol
Prif Awduron: Maes, Michaël, McGill, Mitchell R., da Silva, Tereza Cristina, Abels, Chloé, Lebofsky, Margitta, Weemhoff, James L., Tiburcio, Taynã, Pereira, Isabel Veloso Alves, Willebrords, Joost, Yanguas, Sara Crespo, Farhood, Anwar, Beschin, Alain, Van Ginderachter, Jo A., Penuela, Silvia, Jaeschke, Hartmut, Cogliati, Bruno, Vinken, Mathieu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654513/
https://ncbi.nlm.nih.gov/pubmed/27826632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1885-6
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