Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats

Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonists attenuate pain and inflammation in preclinical models. This study tested whether systemic delivery of an α7 nAChR agonist attenuates neuropathic pain and associated immune-mediated pro-inflammation. Hind paw response thresholds to mechanic...

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Detalhes bibliográficos
Publicado no:J Pain
Main Authors: Loram, Lisa C., Taylor, Frederick R., Strand, Keith A., Maier, Steven F., Speake, Jason D., Jordan, Kristen G., James, John W., Wene, Steven P., Pritchard, Robert C., Green, Heather, Van Dyke, Katherine, Mazarov, Anatoly, Letchworth, Sharon R., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654381/
https://ncbi.nlm.nih.gov/pubmed/23182225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2012.08.009
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