Increasing glioma-associated monocytes leads to increased intratumoral and systemic myeloid-derived suppressor cells in a murine model

BACKGROUND: Patients with glioblastoma multiforme (GBM) exhibit marked intratumoral and systemic immunosuppression. GBM is heavily infiltrated with monocytic cells. Monocytes contacting GBM cells develop features of immunosuppressive myeloid-derived suppressor cells (MDSCs), which are elevated in GB...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Chae, Michael, Peterson, Timothy E., Balgeman, Alexis, Chen, Selby, Zhang, Lei, Renner, Danielle N., Johnson, Aaron J., Parney, Ian F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654350/
https://ncbi.nlm.nih.gov/pubmed/25537019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou343
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