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Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments

Hematopoietic stem cells in mammals are known to reside mostly in the bone marrow, but also transitively passage in small numbers in the blood. Experimental findings have suggested that they exist in a dynamic equilibrium, continuously migrating between these two compartments. Here we construct an i...

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Publicat a:PLoS Comput Biol
Autors principals: Ashcroft, Peter, Manz, Markus G., Bonhoeffer, Sebastian
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5654265/
https://ncbi.nlm.nih.gov/pubmed/28991922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005803
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