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Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB

Alpha-1 antitrypsin (AAT) augmentation therapy involves infusion of plasma-purified AAT to AAT deficient individuals. Whether treatment affects microRNA expression has not been investigated. This study’s objectives were to evaluate the effect of AAT augmentation therapy on altered miRNA expression i...

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Publicat a:Sci Rep
Autors principals: Hassan, Tidi, de Santi, Chiara, Mooney, Catherine, McElvaney, Noel G., Greene, Catherine M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653852/
https://ncbi.nlm.nih.gov/pubmed/29062067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14310-2
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