Direct Screening of Enzyme Activity using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI)

RATIONALE: High-throughput screening (HTS) is a critical step in the drug discovery process. However, most mass spectrometry-based HTS methods require sample cleanup steps prior to analysis. In this work we present the utility of infrared matrix-assisted laser desorption electrospray ionization (IR-...

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Udgivet i:Rapid Commun Mass Spectrom
Main Authors: Nazari, Milad, Ekelöf, Måns, Khodjaniyazova, Sitora, Elsen, Nathaniel L., Williams, Jon D., Muddiman, David C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653407/
https://ncbi.nlm.nih.gov/pubmed/28841760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rcm.7971
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