Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb

Renal resistance to loop diuretics is a frequent complication in a number of kidney disease patients with elusive mechanism. Employing human renal biopsy specimens, albumin overload mouse model, and primary cultures of mouse renal tubular cells, albuminuria effect on NKCC2 expression and function an...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Zhuang, Yibo, Jia, Zhanjun, Hu, Caiyu, Ding, Guixia, Zhang, Xintong, Zhang, Yue, Yang, Guangrui, Rohatgi, Rajeev, Huang, Songming, He, John Ci-Jiang, Zhang, Aihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652664/
https://ncbi.nlm.nih.gov/pubmed/29100270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10257
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