Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb

Renal resistance to loop diuretics is a frequent complication in a number of kidney disease patients with elusive mechanism. Employing human renal biopsy specimens, albumin overload mouse model, and primary cultures of mouse renal tubular cells, albuminuria effect on NKCC2 expression and function an...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhuang, Yibo, Jia, Zhanjun, Hu, Caiyu, Ding, Guixia, Zhang, Xintong, Zhang, Yue, Yang, Guangrui, Rohatgi, Rajeev, Huang, Songming, He, John Ci-Jiang, Zhang, Aihua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652664/
https://ncbi.nlm.nih.gov/pubmed/29100270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10257
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