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Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells

Ursolic acid (UA) is a pentacyclic triterpenoid with recognized anticancer properties. We prepared a series of new A-ring cleaved UA derivatives and evaluated their antiproliferative activity in non-small cell lung cancer (NSCLC) cell lines using 2D and 3D culture models. Compound 17, bearing a clea...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Mendes, Vanessa I. S., Bartholomeusz, Geoffrey A., Ayres, Mary, Gandhi, Varsha, Salvador, Jorge A. R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652311/
https://ncbi.nlm.nih.gov/pubmed/27484517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.07.045
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