IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses

IL-1RA has been used intra-cerebrally to ameliorate neuroinflammatory responses. The present study explored the possibility that the bioactivity of IL-1RA administered intra-cerebrally may be prolonged in the CNS. hIL-1RA was detected in hippocampus from 2 h to 14 d post-ICM treatment. hIL-1RA ameli...

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Publicado en:J Neuroimmunol
Main Authors: Frank, Matthew G., Barrientos, Ruth M., Thompson, Brittany M., Weber, Michael D., Watkins, Linda R., Maier, Steven F.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652306/
https://ncbi.nlm.nih.gov/pubmed/22871632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2012.07.010
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