TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells

Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune pathway. Here we show that airway epithelial cells display an increase in intrace...

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Publicado no:Nat Commun
Main Authors: Alpizar, Yeranddy A., Boonen, Brett, Sanchez, Alicia, Jung, Carole, López-Requena, Alejandro, Naert, Robbe, Steelant, Brecht, Luyts, Katrien, Plata, Cristina, De Vooght, Vanessa, Vanoirbeek, Jeroen A. J., Meseguer, Victor M., Voets, Thomas, Alvarez, Julio L., Hellings, Peter W., Hoet, Peter H. M., Nemery, Benoit, Valverde, Miguel A., Talavera, Karel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651912/
https://ncbi.nlm.nih.gov/pubmed/29057902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01201-3
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