Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy

Optogenetic strategies to restore vision in patients who are blind from end-stage retinal degenerations aim to render remaining retinal cells light sensitive once photoreceptors are lost. Here, we assessed long-term functional outcomes following subretinal delivery of the human melanopsin gene (OPN4...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: De Silva, Samantha R., Barnard, Alun R., Hughes, Steven, Tam, Shu K. E., Martin, Chris, Singh, Mandeep S., Barnea-Cramer, Alona O., McClements, Michelle E., During, Matthew J., Peirson, Stuart N., Hankins, Mark W., MacLaren, Robert E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651734/
https://ncbi.nlm.nih.gov/pubmed/28973921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701589114
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