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FOXO1 opposition of CD8(+) T cell effector programming confers early memory properties and phenotypic diversity

The factors and steps controlling postinfection CD8(+) T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that naive TCF7 (alias “Tcf-1”) expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent expression of the memory...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Delpoux, Arnaud, Lai, Chen-Yen, Hedrick, Stephen M., Doedens, Andrew L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651728/
https://ncbi.nlm.nih.gov/pubmed/28973925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618916114
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