Pretransplant 4β‐hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation

AIMS: The CYP3A metric 4β‐hydroxycholesterol (4βOHC) has been shown to correlate with tacrolimus steady‐state apparent oral clearance (CL/F). Recently, pretransplant 4βOHC was shown not to predict tacrolimus CL/F after transplantation in a cohort of renal recipients (n = 79). The goal of the current...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Vanhove, Thomas, Hasan, Mahmoud, Annaert, Pieter, Oswald, Stefan, Kuypers, Dirk R. J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Pharmacokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651327/
https://ncbi.nlm.nih.gov/pubmed/28603840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13343
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