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t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit
t-Darpp is the truncated form of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa (Darpp-32) and has been demonstrated to confer resistance to trastuzumab, a Her2-targeted anticancer agent, via sustained signaling through the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt pathway...
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| Published in: | Cell Signal |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5651189/ https://ncbi.nlm.nih.gov/pubmed/28867659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.08.012 |
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