Dephosphorylation is the Mechanism of Fibroblast Growth Factor Inhibition of Guanylyl Cyclase-B

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations of guanylyl cyclase-B (GC-B, also called NPRB or NPR2) cause dwarfism. FGF exposure inhibits GC-B activity in a chondrocyte cell line, but the mechanism of the inactivation is not known. Here, we report th...

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Pubblicato in:Cell Signal
Autori principali: Robinson, Jerid W., Egbert, Jeremy R., Davydova, Julia, Schmidt, Hannes, Jaffe, Laurinda A., Potter, Lincoln R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651182/
https://ncbi.nlm.nih.gov/pubmed/28964968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.09.021
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