Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain

Pain and depression often co-occur, but the underlying mechanisms have not been elucidated. Here, we used the spared nerve injury (SNI) model in mice to induce both neuropathic pain and depression-like behavior. We investigated whether brain IL-1 signaling and activity of kynurenine 3-monoxygenase (...

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Bibliographic Details
Published in:Brain Behav Immun
Main Authors: Laumet, Geoffroy, Zhou, Wenjun, Dantzer, Robert, Edralin, Jules D., Huo, XiaoJiao, Budac, David P., O’Connor, Jason C., Lee, Anna W., Heijnen, Cobi J., Kavelaars, Annemieke
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650931/
https://ncbi.nlm.nih.gov/pubmed/28709913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.07.008
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