Osteoblast Hypoxia-Inducible Factor-1α Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway

Functional cross-talk between osteoblasts and osteoclasts is a key process for bone homeostasis. Although osteoblast hypoxia-inducible factor-1α (HIF-1α) pathway activation results in impaired osteoclastogenesis via the direct regulation of osteoprotegerin (OPG), it is unclear whether there are othe...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kang, Hui, Yang, Kai, Xiao, Lianbo, Guo, Lei, Guo, Changjun, Yan, Yufei, Qi, Jin, Wang, Fei, Ryffel, Bernhard, Li, Changwei, Deng, Lianfu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650688/
https://ncbi.nlm.nih.gov/pubmed/29085370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01312
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