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A Split-Abl Kinase for Direct Activation in Cells
To dissect the cellular roles of individual kinases, it is useful to design tools for their selective activation. We describe the engineering of a split-cAbl kinase(sKin-Abl) that is rapidly activated in cells with rapamycin and allows temporal, dose, and compartmentalization control. Our design str...
Shranjeno v:
| izdano v: | Cell Chem Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5650542/ https://ncbi.nlm.nih.gov/pubmed/28919041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.007 |
| Oznake: |
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