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Phase II Study Evaluating the Combination of Sorafenib and Temsirolimus in the Treatment of Radioactive Iodine-Refractory Thyroid Cancer

BACKGROUND: Patients with recurrent and/or metastatic radioactive iodine refractory thyroid carcinomas (RAI-TC) have limited treatment options. Sorafenib, an oral kinase inhibitor, is FDA approved for the treatment of RAI-TC but demonstrated low response rates (12.2%) as a single agent in the first...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Sherman, Eric J., Dunn, Lara, Ho, Alan L., Baxi, Shrujal, Ghossein, Ronald A., Fury, Matthew G., Haque, Sofia, Sima, Cami, Cullen, Grace, Fagin, James, Pfister, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650535/
https://ncbi.nlm.nih.gov/pubmed/28662274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30861
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