Heme Binding Biguanides Target Cytochrome P450 Dependent Cancer Cell Mitochondria

The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport cha...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia, Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A. D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien, Daniel S., Stamschror, Justin D., Alvarez, Juan, Luna, Fernando, Galván, Adela, Bae, Young Kyung, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Norris, Beverly, Flory, Craig M., Schumacher, Robert J., O’Sullivan, M. Gerard, Cao, Qing, Chu, Haitao, Lipscomb, John D., Atkins, William M., Gupta, Kalpna, Kelekar, Ameeta, Blair, Ian A., Capdevila, Jorge H., Falck, John R., Sligar, Stephen G., Poulos, Thomas L., Georg, Gunda, Ambrose, Elizabeth, Potter, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650512/
https://ncbi.nlm.nih.gov/pubmed/28919040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.009
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