Daam2 driven degradation of VHL promotes gliomagenesis

Von Hippel-Landau (VHL) protein is a potent tumor suppressor regulating numerous pathways that drive cancer, but mutations in VHL are restricted to limited subsets of malignancies. Here we identified a novel mechanism for VHL suppression in tumors that do not have inactivating mutations. Using devel...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zhu, Wenyi, Krishna, Saritha, Garcia, Cristina, Lin, Chia-Ching John, Mitchell, Bartley D, Scott, Kenneth L, Mohila, Carrie A, Creighton, Chad J, Yoo, Seung-Hee, Lee, Hyun Kyoung, Deneen, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650470/
https://ncbi.nlm.nih.gov/pubmed/29053101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31926
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