The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

Sphingosine-1-phosphate (S1P) is generated through phosphorylation of sphingosine by sphingosine kinases (Sphk1 and Sphk2). We show that sphk2 maternal-zygotic mutant zebrafish embryos (sphk2(MZ)) display early developmental phenotypes, including a delay in epiboly, depleted S1P levels, elevated lev...

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Vydáno v:eLife
Hlavní autoři: Mendelson, Karen, Pandey, Suveg, Hisano, Yu, Carellini, Frank, Das, Bhaskar C, Hla, Timothy, Evans, Todd
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650468/
https://ncbi.nlm.nih.gov/pubmed/28956531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21992
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