Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies

Lysine-specific demethylase 1 (LSD1) – also known as KDM1A – is the first identified histone demethylase. LSD1 is highly expressed in numerous human malignancies and has recently emerged as a target for anticancer drugs. Owing to the presence of several functional domains, we speculated that LSD1 co...

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Udgivet i:Oncotarget
Main Authors: Chao, Angel, Lin, Chiao-Yun, Chao, An-Ning, Tsai, Chia-Lung, Chen, Ming-Yu, Lee, Li-Yu, Chang, Ting-Chang, Wang, Tzu-Hao, Lai, Chyong-Huey, Wang, Hsin-Shih
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650353/
https://ncbi.nlm.nih.gov/pubmed/29088798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20158
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