Enterovirus 71 protease 2A(pro) and 3C(pro) differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication

Endoplasmic reticulum-associated degradation (ERAD) is an important function for cellular homeostasis. The mechanism of how picornavirus infection interferes with ERAD remains unclear. In this study, we demonstrated that enterovirus 71 (EV71) infection significantly inhibits cellular ERAD by targeti...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Wang, Tao, Wang, Bei, Huang, He, Zhang, Chongyang, Zhu, Yuanmei, Pei, Bin, Cheng, Chaofei, Sun, Lei, Wang, Jianwei, Jin, Qi, Zhao, Zhendong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650186/
https://ncbi.nlm.nih.gov/pubmed/28985237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006674
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