Enterovirus 71 protease 2A(pro) and 3C(pro) differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication

Endoplasmic reticulum-associated degradation (ERAD) is an important function for cellular homeostasis. The mechanism of how picornavirus infection interferes with ERAD remains unclear. In this study, we demonstrated that enterovirus 71 (EV71) infection significantly inhibits cellular ERAD by targeti...

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Publicado en:PLoS Pathog
Autores principales: Wang, Tao, Wang, Bei, Huang, He, Zhang, Chongyang, Zhu, Yuanmei, Pei, Bin, Cheng, Chaofei, Sun, Lei, Wang, Jianwei, Jin, Qi, Zhao, Zhendong
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650186/
https://ncbi.nlm.nih.gov/pubmed/28985237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006674
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