In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells

We explored the utility of neural stem cells (NSCs) as an in vitro model for evaluating preclinical therapeutics in succinic semialdehyde dehydrogenase-deficient (SSADHD) mice. NSCs were obtained from aldh5a1(+/+) and aldh5a1(-/-) mice (aldh5a1 = aldehyde dehydrogenase 5a1 = SSADH). Multiple paramet...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Vogel, Kara R., Ainslie, Garrett R., Jansen, Erwin E., Salomons, Gajja S., Roullet, Jean-Baptiste, Gibson, K. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650182/
https://ncbi.nlm.nih.gov/pubmed/29053743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186919
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