Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea

Intermittent hypoxia (IH) induces activation of the integrated stress response (ISR), but its role in IH-induced visceral white adipose tissue (vWAT) insulin resistance is unknown. CHOP is activated by chronic ISR, whereas GADD34 dephosphorylates the subunit of translation initiation factor 2 (eIF2α...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Khalyfa, Abdelnaby, Qiao, Zhuanhong, Gileles-Hillel, Alex, Khalyfa, Ahamed A., Akbarpour, Mahzad, Popko, Brian, Gozal, David
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2017
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650089/
https://ncbi.nlm.nih.gov/pubmed/28594573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0057OC
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