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Activation of the Integrated Stress Response and Metabolic Dysfunction in a Murine Model of Sleep Apnea
Intermittent hypoxia (IH) induces activation of the integrated stress response (ISR), but its role in IH-induced visceral white adipose tissue (vWAT) insulin resistance is unknown. CHOP is activated by chronic ISR, whereas GADD34 dephosphorylates the subunit of translation initiation factor 2 (eIF2α...
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| Publicado no: | Am J Respir Cell Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5650089/ https://ncbi.nlm.nih.gov/pubmed/28594573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0057OC |
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