Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment

INTRODUCTION: Ammonia-induced oxidative stress, mitochondrial dysfunction, and energy crisis are known as some the major mechanisms of brain injury in hepatic encephalopathy (HE). Hyperammonemia also affects the liver and hepatocytes. Therefore, targeting mitochondria seems to be a therapeutic point...

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Bibliografiske detaljer
Udgivet i:Clin Exp Hepatol
Main Authors: Niknahad, Hossein, Jamshidzadeh, Akram, Heidari, Reza, Zarei, Mahdi, Ommati, Mohammad Mehdi
Format: Artigo
Sprog:Inglês
Udgivet: Termedia Publishing House 2017
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649485/
https://ncbi.nlm.nih.gov/pubmed/29062904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/ceh.2017.68833
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