Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment

INTRODUCTION: Ammonia-induced oxidative stress, mitochondrial dysfunction, and energy crisis are known as some the major mechanisms of brain injury in hepatic encephalopathy (HE). Hyperammonemia also affects the liver and hepatocytes. Therefore, targeting mitochondria seems to be a therapeutic point...

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Detalles Bibliográficos
Publicado en:Clin Exp Hepatol
Main Authors: Niknahad, Hossein, Jamshidzadeh, Akram, Heidari, Reza, Zarei, Mahdi, Ommati, Mohammad Mehdi
Formato: Artigo
Idioma:Inglês
Publicado: Termedia Publishing House 2017
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649485/
https://ncbi.nlm.nih.gov/pubmed/29062904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/ceh.2017.68833
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