Components in Plasma-Derived Factor VIII, But Not in Recombinant Factor VIII Downregulate Anti-Inflammatory Surface Marker CD163 in Human Macrophages through Release of CXCL4 (Platelet Factor 4)

BACKGROUND: Hemarthrosis, or bleeding into the joints, is a hallmark of hemophilia. Heme triggers oxidative stress, inflammation, and destruction of cartilage and bone. The haptoglobin-CD163-heme oxygenase-1 (HO-1) pathway circumvents heme toxicity through enzymatic degradation of heme and transcrip...

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Detalhes bibliográficos
Publicado no:Transfus Med Hemother
Main Authors: Bertling, Anne, Brodde, Martin F., Visser, Mayken, Treffon, Janina, Fennen, Michelle, Fender, Anke C., Kelsch, Reinhard, Kehrel, Beate E.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger GmbH 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649264/
https://ncbi.nlm.nih.gov/pubmed/29070980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000472157
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