Fatal Pertussis in the Neonatal Mouse Model Is Associated with Pertussis Toxin-Mediated Pathology beyond the Airways

In infants, Bordetella pertussis can cause severe disease, manifested as pronounced leukocytosis, pulmonary hypertension, and even death. The exact cause of death remains unknown, and no effective therapies for treating fulminant pertussis exist. In this study, a neonatal mouse model of critical per...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Scanlon, Karen M., Snyder, Yael G., Skerry, Ciaran, Carbonetti, Nicholas H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Bacterial Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649019/
https://ncbi.nlm.nih.gov/pubmed/28784932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00355-17
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